There is contortion of the surface of the cells owing to the additional force. Endothelial moieties are required for adhesion of the molecules. It has been found that the Ligand reception bonds are non covalent in nature and stronger. The aggregate force of the adhesion between the cancer cells and endothelium is able to counter the external pressure exerted by the cancer cells owing to the blood flow. Ultimately, it is the relationship between these two aspects that determine the strength of the specific cancer cell adhesion to the endothelial cell . Cancer cell adhesion to endothelial cells is controlled by the vascular selections that are found as a complementary to the carbohydrate ligands. These selectins are transmembrane glycoproteins that are present in the endothelial structure and form transient bonds. This is an integral aspect in the initial steps of the cells adhesion cases. L-selectin E-selectin and P-selectin bind to their PSGL-1 and sialyl Lewisx-like carbohydrates. P-selectin glycoprotein ligand-1 is a glycoprotein is found on the endothelial cells it has been found that it binds majorly with the the P-selectin. PSGL is also found to bind with the L selectin and the E- Selectin. There is a need to understand the molecular measurement and elasticity of these compounds to further understand the dynamics of the situation. Alternatively, changes in the thermal fluctuations by microscopic cantilever are also used by studying the actual impact and the biophysical aspect of these PSGL measurements. This process of PSGL binding to the Selectin is found to be an imperative process for the initial tethering and rolling mechanism. For the purpose of this analysis, only E-selection is considered. Size, force and torque of the cells are important determinants to understand about the sheer force. It has been observed that the cells adhesion is primarily because of size, volume and sheer force along with the consideration of the torque. For the purpose of understanding about the nuances of rolling, a 3D computational model that encompasses the Monte Carlo method was developed. It was found from this analysis that hydrodynamic and receptor-ligand bond forces explain about the ligand adhesion in detail . To understand the dynamics of the cell adhesion, there is a need to look into the biophysical nuances and its aspects. Arrhenius equation has been to develop successful models to explain about the nuances of the cell adhesion.